https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests involve:
1996, very first mesoscopic cost density waves equipment; and very first electrical measurements on one metal nanocluster among nanoelectrodes
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That is a aspiration of mine and we established to work using a scrumptious dose of naivety. This is certainly something that will probably generate spectacular leads to the extended term, but that does not subject. You shouldn't only want to work within the issues of tomorrow, but also within the issues of the day soon after tomorrow.’
Microbiology has only been around to get a century, given that we started to examine micro-organisms far more severely. I assumed nanobiology was an ideal phrase, due to the fact all molecular biological appropriate interactions happen with the nanoscale: a protein is a number of nanometres in dimensions, DNA is 2 nm thick.’
‘In the beginning we checked out Organic systems using a Actual physical view and acted on the basis on the applications we knew. It took a couple of years right before we began Operating additional on the big biological concerns. I then began to simply call it nanobiology, a time period that did not exist at the time.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
In 1993, to be a young and eager affiliate professor at Delft College of Technologies, I had to begin with concentrated the analysis initiatives of my team on measuring the electrical conductance of only one conducting-polymer molecule. Inside of two several years, we experienced created a device through which only one wire of the phthalocyaninepolysiloxane polymer was connected involving two intently spaced metal nanoelectrodes.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-creating approach
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from studies of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his investigation has focused on finding out chromatin structure and mobile division with bacteria on chip, when he is additionally seeking to in the end Establish synthetic cells from The underside up.
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Dekker heeft ceesdekker fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style in 2005. (nl)